https://apache-labs.com/community/viewtopic.php?f=13&t=2655
2. Always use DIGU or DIGL (almost always DIGU except for you RTTY types

3. Keep your ALC < 0dB. -1dB is fine. The ALC is an awesome, look-ahead, intelligent soft limiting algorithm, but you don't want or need any compression of your digi mode signal, as in this case compression = distortion. This is as opposed to phone operations, where the compression offered by the ALC may be seen as a desirable feature.
4. Contrary to what is recommended for conventional radios, always set your audio drive level from your digi mode software (WSJT-X, Fldigi, etc.) to -1dB, then set your desired RF output power level with the Drive slider. This is backwards from conventional rigs because in the ANAN series radios the gain in the PA and driver sections is fixed and therefore the entire dynamic range of the amp is always available. The Drive slider merely controls the output from the DAC into the fixed gain of the driver amp and PA sections.
5. Use the Single Calibrate mode of PureSignal to set your linearization prior to commencing operations. I.e. once you have your RF drive where you want it (using "tune" in WSJT-X or Fldigi, for example), use the two-tone feature (set to use drive power) and click the Single Calibrate button a few times until you get a good solution. Be sure to use DUP mode on the panadapter so you can see what is actually being transmitted for IMD. Note that the reason you can't use the automatic mode is because you are not hitting 0dB ALC where PureSignal kicks off automatic measurements, and also because the digi mode waveforms are not kind to the automatic algorithm.
6. If you are not working an entire sub-band a la FT8, i.e. if you know you are always going to center up on the 1500Hz sweet spot and then work a PSK, Olivia or RTTY signal or the like, then set your transmit passband to match your transmitted waveform bandwidth.
Do all of the above and you'll have a squeaky clean digi mode signal.
Special note: you will see noise "bursts" on the waterfall when digital modulations switch instantaneously from one tone to the next. This is normal and is a side effect of the FFT process used to display the panadapter and waterfall. These are particularly evident and noticeable when using one-tone-at-a-time modes like JT and FT modes. There is generally no need for concern about this.